Proteome Profiling Among Aging Cell Lines

Characterization of the proteome provides direct information on disease-associated pathways during the onset and progression of Alzheimer’s Disease (AD). In this project, we employed high-resolution mass spectrometry to quantify the proteomes of AD cell cultures using multiplexed quantification. The following phenotypes were measured: Control (Nt), lamin A mutation (La), progerin (Pg), classical AD mutation (AppNt), AD mutation with lamin A (AppLa), and AD mutation with progerin (AppPg).