Structure of the SFTSV L protein stalled at early elongation with the endonuclease domain in a raised conformation [EARLY-ELONGATION-ENDO]

Structure of the SFTSV L protein stalled at early elongation with the endonuclease domain in a raised conformation [EARLY-ELONGATION-ENDO] Descriptor: 5'-O-[(S)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]uridine, MAGNESIUM ION, RNA (5'-R(*AP*CP*AP*CP*AP*GP*AP*GP*AP*CP*GP*CP*CP*CP*AP*GP*A)-3'), ... Authors: Williams, H.M, Thorkelsson, S.R, Vogel, D, Milewski, M, Busch, C, Cusack, S, Grunewald, K, Quemin, E.R.J, Rosenthal, M. Deposit date: 2022-08-18 Release date: 2023-01-18 Last modified: 2025-07-02 Method: ELECTRON MICROSCOPY (3.6 Å) Cite: Structural insights into viral genome replication by the severe fever with thrombocytopenia syndrome virus L protein. Nucleic Acids Res., 51, 2023处于早期延伸停滞状态的发热伴血小板减少综合征病毒（Severe Fever with Thrombocytopenia Syndrome Virus, SFTSV）L蛋白结构，其核酸内切酶结构域处于凸起构象 [EARLY-ELONGATION-ENDO] 标识物：5'-O-[(S)-羟基{[(S)-羟基(膦酰氧基)膦酰基]氨基}膦酰基]尿苷、镁离子、RNA（5'-R(*AP*CP*AP*CP*AP*GP*AP*GP*AP*CP*GP*CP*CP*CP*AP*GP*A)-3'），…… 作者：Williams, H.M、Thorkelsson, S.R、Vogel, D、Milewski, M、Busch, C、Cusack, S、Grunewald, K、Quemin, E.R.J、Rosenthal, M. 存档日期：2022-08-18 发布日期：2023-01-18 最后修改日期：2025-07-02 实验方法：电子显微镜（分辨率3.6埃） 引用文献：《发热伴血小板减少综合征病毒L蛋白介导病毒基因组复制的结构解析》，《核酸研究》，第51卷，2023年