Effects of peptides on the development of AA-amyloidosis in mice.

$diluted peptide solutions matured for 1 month.*diluted peptide solutions matured for 1 year.£amyloid grade semiquantitatively estimated according to 0, no amyloid found; 1+, one or two amyloid-containing fragments/slide; 2+, more than two amyloid fragments/slide but no coalescent areas; 3+, amyloid-containing fragments with coalescence; 4+, extensive amyloidosis. The amyloid grade of each positive mouse is given.#Number of mice with amyloidosis/total number of animals. Several animals had to be taken out from the experiment due to development of skin ulcers at the site of silver nitrate injection. None of these animals had developed amyloid deposits.N/A, not applicable.Peptides 1–12 were dissolved in dimethyl sulfoxide and then diluted in water. Peptide 13 was directly dissolved in water.