Nuclear miRNA-mediated gene silencing dependent on Argonaute proteins is required for embryonic stem cell differentiation [1_Differentiation_rna_seq]

干细胞与再生医学数据中心2022-02-20 更新2024-03-06 收录

下载链接：

http://data.iscr.ac.cn/Article?id=6f2ef1e645d170b404c6c843ee05161c

下载链接

链接失效反馈

官方服务：

资源简介：

Here, we show that embryonic stem cells (ESCs) and muscle stem cells contain high levels of nuclear AGO proteins and that in ESCs nuclear AGO2 protein activity is sufficient to allow for differentiation. Transcriptome-wide mapping of binding sites at nucleotide resolution revealed that nuclear AGO2 expands its target sequence repertoire in a miRNA-dependent manner to include intronic sequences to induce post-transcriptional gene silencing

提供机构：

NIH

创建时间：

2022-02-20