Additional file 1 of Tumor sequencing is useful to refine the analysis of germline variants in unexplained high-risk breast cancer families

Additional file 1: Table S1. List of the 735 genes selected for germline variant analysis. Data regarding familial syndrome was obtained from the supplementary data of Zhang et al. [15] and updated by literature query. Table S2. List of germline variants retained after filtering. Information about their characteristics and their allele-specific read depths in the tumor. Table S3. Assessment by MutSigCV of the statistical significance of the clustering of somatic mutations in putative cancer genes. Table S4. Clinical characteristics of the affected relatives from which both germline as well as tumor DNA could be obtained. Table S5. Details regarding the multidisciplinary discussion of variants of interest.