Metal–Organic Framework Nodes Support Single-Site Magnesium–Alkyl Catalysts for Hydroboration and Hydroamination Reactions

Here
we present the first example of a single-site main group catalyst
stabilized by a metal–organic framework (MOF) for organic transformations.
The straightforward metalation of the secondary building units of
a Zr-MOF with Me2Mg affords a highly active and reusable
solid catalyst for hydroboration of carbonyls and imines and for hydroamination
of aminopentenes. Impressively, the Mg-functionalized MOF displayed
very high turnover numbers of up to 8.4 × 104 for
ketone hydroboration and could be reused more than 10 times. MOFs
can thus be used to develop novel main group solid catalysts for sustainable
chemical synthesis.