Biochemical simulation methods that account for spatial and stochastic detail.

aGMP is event-based for reactions and uses fixed time steps for diffusion. bMCell uses an event-based scheduling system in which short steps are used for fast processes and long steps for slow processes. cCell++ represents small molecules, such as metabolites, as concentrations on a coarse lattice and large molecules, such as enzymes, as individual particles in continuous space. dGFRD is in process of being added to E-Cell.