Iridium-Catalyzed Enantioselective Allylic Substitution of Vinylcyclopropanes by Carboxylic Acids

An efficient method for a highly
regio- and enantioselective allylic
substitution of vinylcyclopropanes using carboxylic acids as oxygen
nucleophile via iridium catalysis has been developed. This represents
a highly atom-economic approach for the synthesis of synthetically
useful chiral building blocks in high yields. The practical utility
of this method is demonstrated by the application of the products
in useful transformations.