Crystal structure of the amino-terminal domain of HSP90 from Leishmania major, LMJF33.0312:M1-K213 in the presence of 17-DMAP-geldanamycin

Crystal structure of the amino-terminal domain of HSP90 from Leishmania major, LMJF33.0312:M1-K213 in the presence of 17-DMAP-geldanamycin Descriptor: (4E,6Z,8S,9S,10E,12S,13R,14S,16R)-19-{[3-(dimethylamino)propyl]amino}-13-hydroxy-8,14-dimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18-pentaen-9-yl carbamate, Heat shock protein 83-1 Authors: Wernimont, A.K, Tempel, W, Lin, Y.H, Hutchinson, A, MacKenzie, F, Fairlamb, A, Cossar, D, Zhao, Y, Schapira, M, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Weigelt, J, Ferguson, M.A.J, Hui, R, Pizarro, J.C, Hills, T, Structural Genomics Consortium (SGC) Deposit date: 2010-12-28 Release date: 2011-02-23 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Crystal structure of the amino-terminal domain of HSP90 from Leishmania major, LMJF33.0312:M1-K213 in the presence of 17-DMAP-geldanamycin. To be Published

利什曼原虫（Leishmania major）来源的热休克蛋白90（HSP90）氨基末端结构域的晶体结构，对应样本LMJF33.0312:M1-K213，实验体系添加17-DMAP-格尔德霉素（17-DMAP-geldanamycin）。结构描述符：(4E,6Z,8S,9S,10E,12S,13R,14S,16R)-19-{[3-(二甲氨基)丙基]氨基}-13-羟基-8,14-二甲氧基-4,10,12,16-四甲基-3,20,22-三氧代-2-氮杂双环[16.3.1]二十二碳-1(21),4,6,10,18-五烯-9-基氨基甲酸酯，热休克蛋白83-1（Heat shock protein 83-1）。作者：Wernimont, A.K.、Tempel, W.、Lin, Y.H.、Hutchinson, A.、MacKenzie, F.、Fairlamb, A.、Cossar, D.、Zhao, Y.、Schapira, M.、Arrowsmith, C.H.、Edwards, A.M.、Bountra, C.、Weigelt, J.、Ferguson, M.A.J.、Hui, R.、Pizarro, J.C.、Hills, T.，结构基因组学联盟（Structural Genomics Consortium, SGC）。提交日期：2010年12月28日，发布日期：2011年2月23日，最后修改日期：2023年9月13日。实验方法：X射线衍射（X-RAY DIFFRACTION），分辨率2.1埃（2.1 Å）。引用信息：《利什曼原虫HSP90氨基末端结构域在17-DMAP-格尔德霉素存在下的晶体结构（LMJF33.0312:M1-K213）》，待发表。