Additional file 1 of DNA methylation loci in placenta associated with birthweight and expression of genes relevant for early development and adult diseases

Additional file 1: Additional Table 1. Comparison of demographic characteristics of women with placental samples and women in the overall NICHD Fetal Growth Studies. Additional Table 2. Association between placental DNA methylation of 15 birthweight-associated CpG sites and gestational age at delivery. Additional Table 3. Regulatory region enrichment of the birthweight-associated CpG sites. A. regulatory features from placenta-specific 15-chromatin state annotation (ChromHMM v1.9). B. CpG island locations. C. Transcription factors. Additional Table 4. Enrichment for tissue-specific DNase 1 hypersensitivity sites (DHSs) of the top 100 CpGs associated with birthweight based on experimentally derived Functional element Overlap analysis of Regions from EWAS (eFORGE). Additional Table 5. Single nucleotide polymorphisms significantly associated with DNA methylation at three CpG sites (meQTLs) in the mQTL database (http://www.mqtldb.org/). Additional Table 6. Previously known associations between the birthweight-associated CpG sites and phenotypes. Additional Table 7. Published CpG sites associated with maternal cardiometabolic traits and adult cardiometabolic traits. Additional Table 8. CpG sites associated with maternal cardiometabolic traits and adult cardiometabolic traits in published studies as well as with birthweight in the present study (FDR <0.05).