Role of human dural fibroblasts in the angiogenic responses of human endothelial cells: an in vitro dural model for EDAS

To determine whether dural fibroblasts (DuF) under IL-1ß-mediated wound conditions, release pro-angiogenic factors, and promote angiogenic properties in human endothelial cells (ECs). DuF were stimulated by pro-inflammatory cytokines interleukin (IL)-1ß, and transcriptome sequencing was then used to identify the differentially expressed genes in the DuF with/without IL-1ß stimulation (DuFCon/DuFIL1b) Overall design: Comparative gene expression profiling analysis of RNA-seq data for Dura fibroblast with/without IL-1ß stimulation.