IL-4 targets correlated with protection by IL-4 in CLL.

Figshare2015-12-02 更新2026-04-29 收录

淋巴细胞白血病分子机制

白细胞介素-4靶点研究

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(†) Mean fold change for comparison IL-4 vs Ctrl.IL-4 targets correlated with protection by IL-4 in CLL.

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2015-12-02

CD8+ T-cell exhaustion induced by leukemic cells drives progression in Chronic Lymphocytic Leukemia

淋巴细胞白血病分子机制

肿瘤免疫微环境中T细胞耗竭

Mechanisms mediating to disease progression from diagnosis in chronic lymphocytic leukemia (CLL) are not fully elucidated. The acquisition of molecular changes at the time of progression has been obse

NIAID Data Ecosystem50

Effects of Blnk reconstitution in BCR-ABL1 driven pre-B cells. Mus musculus

淋巴细胞白血病分子机制

B细胞受体

In order to investigate the function of the adapterprotein Blnk in ALL, we isolated bone marrow cells from Blnk KO mice and transformed them with BCR-ABL1. In a second transduction the BCR-ABL1 driven

NIAID Data Ecosystem40

siRNA-mediated silencing of ETV6/RUNX1 increases the level of mature miR-181a-1.

淋巴细胞白血病分子机制

miRNA调控

(A) Stem-loop sequence of human precursor mir-181a-1. Mature miR-181a (red) and miR181a-1 (blue) are indicated. (B) Validation of miR-181a-1 expression in primary pre-B ALL samples (ETV6/RUNX1-positiv

NIAID Data Ecosystem10

Aberrant RNA expression and splicing in childhood ETV6/RUNX1 acute lymphoblastic leukemia. Aberrant RNA expression and splicing in childhood ETV6/RUNX1 acute lymphoblastic leukemia

淋巴细胞白血病分子机制

儿童恶性肿瘤转录组学

ETV6/RUNX1 E/R -positive acute lymphoblastic leukemia (ALL), as one of the most common childhood malignancies, its pathogenesis and mechanism remain to be elucidated comprehensively. Global gene expre

NIAID Data Ecosystem50

RBPJ and H3K27ac chromatin IP with sequencing of CLL cells with hyperactivated Notch1 compared to control CLL cells [ChIP-seq]. RBPJ and H3K27ac chromatin IP with sequencing of CLL cells with hyperactivated Notch1 compared to control CLL cells [ChIP-seq]

淋巴细胞白血病分子机制

Notch信号通路

NOTCH1 gain-of-function mutations are recurrent in B cell chronic lymphocytic leukemia (B-CLL), where they are associated with accelerated disease progression and refractoriness to chemotherapy. The s

NIAID Data Ecosystem30

IL-4 targets correlated with protection by IL-4 in CLL.

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