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Proteolytic processing of galectin-3 is crucial for host microbiome homeostasis

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NIAID Data Ecosystem2026-05-01 收录
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https://www.omicsdi.org/dataset/pride/PXD037000
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To identify relevant substrates for meprin α/β heterodimers, we applied mass spectrometry-based N-terminomics of mouse colon tissue as well as of human Caco-2 cells and identified galectin-3 as a novel intestinal substrate. The proteolytic processing of galectin-3 by meprin α/β heterodimers plays a key role in the maintenance of the host-microbiome homeostasis within the colon.
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2023-05-10
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