Overall flux control exerted by different enzymes in glycolysis.

The general flux control exerted by a reaction is quantified by , the sum of squared scaled control coefficients. Control coefficients were calculated at the operating state from the large-scale yeast model and from the five original modelsa used to define the flux and concentration values. Only a selection of enzymes appearing in the original models are shownb. aModel references are as follows BM:61 [43], BM:64 [44], BM:172 [45], BM:176 [46], and BM:177 [46] bAbbreviations as follows: ADH, alcohol dehydrogenase, reverse reaction; ATPase, cytosolic ATPase; Eno, enolase; FBPA, fructose-bisphosphate aldolase; G3PDH, glycerol-3-phosphate dehydrogenase; GAL3PD, glyceraldehyde-3-phosphate dehydrogenase; GluT, glucose transport; HXK, hexokinase; PFK, phosphofructokinase; PGK, phosphoglycerate kinase; PGM, phosphoglycerate mutase.