Genome-wide maps of chromatin state in epiblast stem cells and nodal inhibited ebiblast stem cells
收藏干细胞与再生医学数据中心2022-05-21 更新2024-03-06 收录
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http://data.iscr.ac.cn/Article?id=4d6898026e9e56b5c3c966742ac63b82
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资源简介：
We reported H3K4me3, H3K27ac and H3K27me3 histone modification in EpiSCs and Nodal inhibited EpiSCs(EpiSCS/F). Using ChIP sequencing, we demonstrate that the active modification of H3K4me3 and H3K27ac level are higher in EpiSCS/F, suggesting EpiSCsS/F were in an active chromatin state. Interestingly, H3K27me3, the supressive modification enriched more in EpiSCS/F down regulated genes, suggesting H3K27me3 plays pivital roles in regulating gene expression.
提供机构：
Shanghai Institute of Biochemistry and Cell Biology
创建时间：
2022-05-21
