Structure of the non-canonical CTLH E3 substrate receptor WDR26 bound to NMNAT1 substrate

Structure of the non-canonical CTLH E3 substrate receptor WDR26 bound to NMNAT1 substrate Descriptor: BETA-NICOTINAMIDE RIBOSE MONOPHOSPHATE, Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1, WD repeat-containing protein 26, ... Authors: Chrustowicz, J, Sherpa, D, Schulman, B.A. Deposit date: 2023-08-30 Release date: 2024-05-15 Last modified: 2025-07-02 Method: ELECTRON MICROSCOPY (3.8 Å) Cite: Non-canonical substrate recognition by the human WDR26-CTLH E3 ligase regulates prodrug metabolism. Mol.Cell, 84, 2024结合于烟酰胺单核苷酸腺苷转移酶1（Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1，NMNAT1）底物的非经典CTLH E3泛素连接酶底物受体WDR26的结构 描述：β-烟酰胺核糖一磷酸（β-N-NICOTINAMIDE RIBOSE MONOPHOSPHATE）、烟酰胺/烟酸单核苷酸腺苷转移酶1、含WD重复序列蛋白26（WD-repeat-containing protein 26，WDR26）…… 作者：Chrustowicz J、Sherpa D、Schulman B.A. 存档日期：2023-08-30 发布日期：2024-05-15 最后更新日期：2025-07-02 实验方法：电子显微镜（分辨率3.8埃） 引用文献：人类WDR26-CTLH E3泛素连接酶通过非经典底物识别调控前药代谢。《分子细胞》（Mol.Cell）, 84, 2024