Cobalt-Catalyzed Asymmetric Hydroboration/Cyclization of 1,6-Enynes with Pinacolborane
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https://figshare.com/articles/dataset/Cobalt-Catalyzed_Asymmetric_Hydroboration_Cyclization_of_1_6-Enynes_with_Pinacolborane/4974989
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资源简介：
We report a cobalt-catalyzed asymmetric
hydroboration/cyclization
of 1,6-enynes with catalysts generated from Co(acac)2 and
chiral bisphosphine ligands and activated in situ by reaction with
pinacolborane (HBpin). A variety of oxygen-, nitrogen-, and
carbon-tethered 1,6-enynes underwent this asymmetric transformation,
yielding both alkyl- and vinyl-substituted boronate esters containing
chiral tetrahydrofuran, cyclopentane, and pyrrolidine moieties with
high to excellent enantioselectivities (86%–99% ee).
创建时间：
2017-05-04
