Lack of Period1 accelerates colorectal tumorigeneses in APCmin/+ mice

Clock genes drive the circadian rhythm in each cell, and Period1 (Per1) is one of the core genes in mammals. When the clock genes lose their functions due to deficiency, various behavioral and physiological functions are altered. Although many pathological studies have been conducted on clock genes and cancers, the results could be more consistent. In the present study, we aimed to clarify how the lack of Per1 affects the development and progression of colorectal cancer. We recorded survival days and calculated survival rates, measured the number of polyps, performed histological evaluation, and measured β-catenin expression using ApcMin/+Per1-/- mice. The results showed that loss of Per1 caused variation in the survival rate of mice, increased the number of polyps, and increased β-catenin expression. These results suggest that Per1 plays a role in suppressing the development and progression of colorectal cancer.