Rhodium-Catalyzed Regio‑, Diastereo‑, and Enantioselective Three-Component Carboamination of Dienes via C–H Activation

Reported herein is the rhodium-catalyzed
enantioselective three-component
coupling of arene, diene, and dioxazolone that occurs via C–H
activation en route to allyl intermediate. This carboamination reaction
affords chiral allylic amines in 1,2-selectivity, E-selectivity, and enantioselectivity, with electrophilic amination
of the π-allyl species being both regio- and enantio-determining.

本文报道了一种通过C-H活化途径至烯丙基中间体的过程中发生的钯催化、手性选择性的三组分偶联反应，该反应涉及芳烃、二烯和二氧杂唑酮。该羰基氨化反应能够以1,2选择性、E选择性和对映选择性合成手性烯丙基胺，其中π-烯丙基物种的亲电氨化反应同时决定了区域选择性和对映选择性。