Inflammatory molecular endotypes of nasal polyps derived from Caucasian and Japanese populations. Inflammatory molecular endotypes of nasal polyps derived from Caucasian and Japanese populations

Chronic rhinosinusitis with nasal polyps is a hallmaerk disease in the field of upper airway immunity and chronic inflammation. Diverse inflammatory patterns between nasal polyps have been described in patients that hail from disparate racial and geographic backgrounds. However, it remains unclear whether these immunologic differences in nasal polyps between racial groups are driven by unique molecular mechanisms. We interrogated the gene expression profiles of nasal polyp tissues from Western (United States) and East Asian (Japan) descent, compared to ethmoid sinus tissue controls. Overall design: Examination of the molecular differences between Caucasian (n=8), Asian CRSwNP (n=9), and contol (n=7) using whole-transcriptome RNA sequencing.