Sensitivity analyses.

Projected Estimates of Reductions in Cardiovascular Disease from a Dietary Salt Reduction Target of 3 g/day achieved over 30 years (via a linear reduction in intake of 0.1 g/year), in the Main Simulation and According to Various Assumptions about Differential Salt Sensitivity and Blood Pressure Reduction Benefits in the Sensitivity Analyses. MI and stroke incidence includes both new cases and recurrent events.
*Cardiovascular benefit of lowering blood pressure was equivalent to two-thirds of the benefit for a person whose native blood pressure was at that lower blood pressure level [42].
**While the baseline simulation implements the results of a meta-analysis that does not reveal greater salt sensitivity among the elderly [27], we also simulated the case in which each gram reduction in salt intake leads to a greater reduction in blood pressure among older cohorts, as per some clinical trials [31], [32], in which the change in systolic pressure = −0.0598 * (mmol salt reduction)−0.0431 * (age-48)) (see Text S1) [26].