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RNA-seq analysis of brain tissue treated by VEGFC in BDL-induced cirrhotic rat with hepatic encephalopathy

Alliance of Genome Resources2026-08-01 收录

肝病分子机制

脑膜淋巴管生成

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https://www.ncbi.nlm.nih.gov/gds/?term=GSE149227 数据链接链接失效反馈

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Conclusion: Promoting meningeal lymphatic drainage and enhancing waste clearance improves HE. Manipulation of meningeal lymphangiogenesis could be a new therapeutic strategy for the treatment of HE.

应用场景：

干扰素免疫调节

肝病分子机制

Primary murine hepatocytes were isolated from C57Bl/6J (wild type) animals and treated with 1000 U/mL IFN-b for 24h and compared to time-matched untreated controls. Overall design: We sequenced in vit

NIAID Data Ecosystem50

Additional file 2: Movie 1. of Integrated ordination of miRNA and mRNA expression profiles

转录组学

肝病分子机制

360Â° rotation of 3D MDS dispersion ellipses of mRNA functional clusters of ALF livers. Labels are shown in the two last frames (38â 39) at the end of the rotation cycle. If the media player runs con

Figshare2016-12-14 更新30

Table_4_Chenodeoxycholic Acid Modulates Bile Acid Synthesis Independent of Fibroblast Growth Factor 19 in Primary Human Hepatocytes.xlsx

胆汁酸代谢

肝病分子机制

Bile acids (BAs) are detergents essential for intestinal absorption of lipids. Disruption of BA homeostasis can lead to severe liver damage. BA metabolism is therefore under strict regulation by sophi

NIAID Data Ecosystem10

HK4 counteracts lipotoxicity-induced gene expression changes in hepatocytes

非酒精性脂肪肝病治疗

肝病分子机制

A novel positive allosteric modulator of the GABAA receptor, HK4, was reported to exhibit hepatoprotective effects against lipotoxicity-induced apoptosis, DNA damage, inflammation and ER stress in vit

NIAID Data Ecosystem30

Multi-omic analysis unveils biological pathways in peripheral immune system associated to minimal hepatic encephalopathy appearance in cirrhotic patients. Multi-omic analysis unveils biological pathways in peripheral immune system associated to minimal hepatic encephalopathy appearance in cirrhotic patients

肝病分子机制

疾病多组学分析

Patients with liver cirrhosis may develop minimal hepatic encephalopathy (MHE) which affects their quality of life and life span. It has been proposed that a shift in peripheral inflammation triggers

NIAID Data Ecosystem20

RNA-seq analysis of brain tissue treated by VEGFC in BDL-induced cirrhotic rat with hepatic encephalopathy

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