Slow cortical dynamics generate context processing and novelty detection

The cortex amplifies responses to novel stimuli, compared to those elicited by redundant stimuli—a function key to efficiently processing sensory information and building predictive models of the environment. Novelty detection is measured by the “Mismatch Negativity” (MMN) signal, the reduction of which represents the best functional biomarker of schizophrenia. To better understand the circuit mechanisms of novelty detection, we used an auditory “oddball” paradigm and two-photon calcium imaging to measure responses to simple and complex stimuli in neuronal populations across the mouse auditory cortex. Stimulus statistics and complexity generated differences in neural response profiles across contexts and auditory cortical subregions. At the population level, neuronal ensembles separately and reliably encoded basic auditory features, as well as temporal context. Interestingly, stimuli-evoked responses were particularly long-lasting, persisting after the stimuli ended and affecting respon..., Methods of data collection, preprocessing, and analysis are described in detail in the associated article
Data was collected with two-photon calcium imaging in the Auditory Cortex of awake mice that were head fixed and moving on a circular treadmil. Mice were presented with auditory oddball stimuli, and many standards control variation. Raw data were motion corrected, and regions of interest (ROIs) corresponding to cells were demixed with CaImAn. The demixed data is provided here., , # Slow cortical dynamics generate context processing and novelty detection

[https://doi.org/10.5061/dryad.xsj3tx9q6](https://doi.org/10.5061/dryad.xsj3tx9q6)

## Description of the data and file structure

Each .zip file contains all datasets from a single mouse. Mice *M1* - *M10* (\"*missmatch*\") are oddball data that were used for Figures 1, 2, 3A-3F. Mice *M226*, *M4264*, *M4265*, *M4266*, *M4371*, *M4372* are variable ISI experiments (\"*echo*\") used for Figures 3 H-3J. 

Each \"M\" file contains all the datasets collected from the given mouse. Each dataset contains processed calcium imaging data within files ending with \"_results_cnmf_sort.mat\", along with stimulus and imaging information within files ending with \"_processed_data.mat\". Finally, \"*AC_data_list.csv*\" file contains additional information about datasets and mice.

Extended details about the experimental methods and analysis are described in detail in the attached publication.

Extended descriptions for data files:

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