Chaperone-mediated autophagy (CMA) involves the selective lysosomal degradation of cytosolic proteins such as SNCA (synuclein α), a protein strongly implicated in Parkinson disease (PD) pathogenesis.
Lysosomal membrane permeabilization (LMP) is observed under many pathological conditions, leading to cellular dysfunction and death. However, the mechanisms by which lysosomal membranes become leaky <
In vitro assembled 266/297 - 391 tau filaments with KCl (10b) Descriptor: Microtubule-associated protein tau Authors: Lovestam, S, Scheres, S.H.W. Deposit date: 2022-02-10 Release date: 2022-02-23 Las
