Preterm children are at increased risk of insulin resistance, obesity, and cardiovascular disease. We hypothesise that adverse early life events in preterm children may lead to alterations in the gut
The human cytochrome P450 3A4 mono-oxygenates ∼50% of all drugs. Its substrates/products enter/leave the active site by access/exit channels. Here, we perform steered molecular dynamics simulations, p
Chronic Inflammation is a key link between obesity and insulin resistance. We previously showed that two nutrient sensors AMP-activated protein kinase (AMPK) and SIRT1 interact to regulate macrophage
To investigate the mechanisms of lipid-activated protein kinase C (PKC) family, PKCδ or PKCɛ, involved in insulin resistance and fatty acid metabolism, we employed an in vivo adaptation of SILAC to ex
Data are mean ± SD, median (minimum - maximum values) or %. BMI, body mass index; HOMA-IR, homeostasis model assessment - insulin resistance; Met, metformin; SU, sulfonylureas.aData were analyzed usin