DNA methylation changes during prostate cancer lineage transitions
收藏NIAID Data Ecosystem2026-05-10 收录
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE278588
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资源简介：
Conversion to a neuroendocrine phenotype is a known resistance mechanism to androgen receptor-directed therapies in prostate cancer. In this study, we analyze DNA methylation changes associated with neuroendocrine transdifferentiation using a patient-derived xenograft model that recapitulates these lineage transitions. DNA samples from the LTL331 patient-derived xenograft model, developed by Dr. Wang (Vancouver Prostate Centre, PMID: 24356420), were collected at various time points post-castration and analyzed using enzymatic DNA methylation sequencing (EM-seq, PMID: 34140313).
创建时间：
2025-09-23
