Crystal structure of Mycobacterium tuberculosis enoyl reductase (INHA) complexed WITH 1-CYCLOHEXYL-N-(3,5-DICHLOROPHENYL)-5-OXOPYRROLIDINE-3-CARBOXAMIDE

Crystal structure of Mycobacterium tuberculosis enoyl reductase (INHA) complexed WITH 1-CYCLOHEXYL-N-(3,5-DICHLOROPHENYL)-5-OXOPYRROLIDINE-3-CARBOXAMIDE Descriptor: (3S)-1-CYCLOHEXYL-N-(3,5-DICHLOROPHENYL)-5-OXOPYRROLIDINE-3-CARBOXAMIDE, Enoyl-[acyl-carrier-protein] reductase [NADH], NICOTINAMIDE-ADENINE-DINUCLEOTIDE Authors: He, X, Alian, A, Stroud, R.M, Ortiz de Montellano, P.R. Deposit date: 2014-07-10 Release date: 2014-08-20 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (1.62 Å) Cite: Pyrrolidine carboxamides as a novel class of inhibitors of enoyl acyl carrier protein reductase from Mycobacterium tuberculosis J. Med. Chem., 2006

结核分枝杆菌（Mycobacterium tuberculosis）烯酰还原酶（enoyl reductase，INHA）与1-环己基-N-(3,5-二氯苯基)-5-氧代吡咯烷-3-甲酰胺的复合物晶体结构。描述符：(3S)-1-环己基-N-(3,5-二氯苯基)-5-氧代吡咯烷-3-甲酰胺、烯酰-[酰基载体蛋白]还原酶（Enoyl-[acyl-carrier-protein] reductase）[NADH]、烟酰胺腺嘌呤二核苷酸（NICOTINAMIDE-ADENINE-DINUCLEOTIDE）。作者：He, X、Alian, A、Stroud, R.M、Ortiz de Montellano, P.R.。提交日期：2014-07-10。发布日期：2014-08-20。最后修改日期：2023-12-27。实验方法：X射线衍射（X-RAY DIFFRACTION，分辨率1.62 Å）。引用文献：吡咯烷甲酰胺类作为结核分枝杆菌烯酰酰基载体蛋白还原酶的新型抑制剂，《J. Med. Chem.》（Journal of Medicinal Chemistry），2006年。