Cryo-EM structure of the MK-6892-bound human HCAR2-Gi1 complex

Cryo-EM structure of the MK-6892-bound human HCAR2-Gi1 complex Descriptor: 2-[[2,2-dimethyl-3-[3-(5-oxidanylpyridin-2-yl)-1,2,4-oxadiazol-5-yl]propanoyl]amino]cyclohexene-1-carboxylic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... Authors: Mao, C, Gao, M, Zang, S, Zhu, Y, Ma, X, Zhang, Y. Deposit date: 2023-04-26 Release date: 2023-12-06 Last modified: 2025-07-16 Method: ELECTRON MICROSCOPY (2.76 Å) Cite: Orthosteric and allosteric modulation of human HCAR2 signaling complex. Nat Commun, 14, 2023结合MK-6892的人源HCAR2-Gi1复合物冷冻电镜（Cryo-EM）结构 描述：2-[[2,2-二甲基-3-[3-(5-氧代吡啶-2-基)-1,2,4-恶二唑-5-基]丙酰基]氨基]环己烯-1-羧酸、2-乙酰氨基-2-脱氧-β-D-吡喃葡萄糖、鸟苷酸结合蛋白G(I)/G(S)/G(O)亚基γ-2（Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2）…… 作者：Mao C、Gao M、Zang S、Zhu Y、Ma X、Zhang Y 提交日期：2023-04-26 发布日期：2023-12-06 最后更新日期：2025-07-16 检测方法：电子显微镜（分辨率2.76埃） 引用文献：《人源HCAR2信号复合物的正构与变构调控》，《自然-通讯》（Nat Commun），14卷，2023年