Characterizing Lipid Species in Metabolic Dysfunction-associated Steatotic Liver Disease in Persons with Type 1 Diabetes

Although MASLD and lipid species have been extensively examined in persons with type 2 diabetes, much less is known in type 1 diabetes (T1D).We conducted a cross-sectional study of 30 participants with T1D, who were stratified as MASLD (cases) or controls, dependent on the results determined by FibroScan imaging. Fasting targeted lipidomics were measured in all participants. Our results suggest that persons with type 1 diabetes and MASLD have a higher BMI, are likely to be insulin resistant, and display elevated circulating levels of dihydroceramides, ceramides, diacylglycerols, and triacylglycerols, which are strongly associated with the pathogenesis of steatotic liver disease