RNA seq data of HEK293T cells infected with Chikungunya virus

Cytoplasmically-replicating positive-sense (+) single-stranded RNA (ssRNA) viruses are believed to be subjected to a wide range of RNA modifications in their genomes. Here, we focused on one of such viruses, the mosquito-transmitted chikungunya virus (CHIKV), as a model virus to study the landscape of viral RNA modifications in CHIKV-infected human embryonic kidney cells (HEK 293T). RNA-seq analysis at base-resolution showed that the CHIKV RNA does not contain inosine modification at biological relevant levels, only after the overexpression of ADAR1 was possible to trace putative RNA editing sites along the viral genome.