Gene expression in pre-cystic mouse kidneys after Pkd2 deletion.. Gene expression in pre-cystic mouse kidneys after Pkd2 deletion.

To identify early transcriptional changes downstream of Pkd2 mutations that promote cyst formation, we used tamoxifen-inducible CAG-Cre to induce Pkd2 deletion at postnatal day 2 and compared to wild-type mice at postnatal day 6 and 10. We then performed gene expression profiling analysis using data obtained from RNA-seq of whole mouse kidneys. Overall design: Comparative gene expression profiling analysis of RNA-seq data for Pkd2 deleted mouse kidneys vs wild-type.