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Master Regulators of oncogenic KRAS response in Pancreatic Cancer. Mus musculus

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NIAID Data Ecosystem2026-03-09 收录
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https://www.ncbi.nlm.nih.gov/bioproject/PRJNA353591
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We derived a transcriptional signature of oncogenic KRAS by using the KF508 murine pancreatic ductal cell line with an inducible Lox-Stop-Lox (LSL) cassette in front of the KRASG12D oncogene to regulate transcription. This dataset allowed us to study the differential expression profile after oncogenic KRAS induction in mouse. Overall design: Total RNA was extracted from six sets of mock and cre treated ductal cells using Qiagen RNeasy kit. The RNA was labelled and hybridized. This experiment was carried out on 2 Illumina Mousev2 BeadChips using 24 arrays (1 samples per Bead-Chip).
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2016-11-15
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