Structure of MBP-Mcl-1 in complex with ABBV-467
收藏Protein Data Bank Japan2026-03-04 更新2026-04-25 收录
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Structure of MBP-Mcl-1 in complex with ABBV-467 Descriptor: (7R,16R)-19,23-dichloro-10-{[2-(4-{[(2R)-1,4-dioxan-2-yl]methoxy}phenyl)pyrimidin-4-yl]methoxy}-1-(4-fluorophenyl)-20,22-dimethyl-16-[(4-methylpiperazin-1-yl)methyl]-7,8,15,16-tetrahydro-18,21-etheno-13,9-(metheno)-6,14,17-trioxa-2-thia-3,5-diazacyclononadeca[1,2,3-cd]indene-7-carboxylic acid, Maltose/maltodextrin-binding periplasmic protein,Induced myeloid leukemia cell differentiation protein Mcl-1, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose Authors: Judge, R.A, Judd, A.S, Souers, A.J. Deposit date: 2022-09-22 Release date: 2023-10-25 Last modified: 2026-03-04 Method: X-RAY DIFFRACTION (2.406 Å) Cite: Selective MCL-1 inhibitor ABBV-467 is efficacious in tumor models but is associated with cardiac troponin increases in patients. Commun Med (Lond), 3, 2023
创建时间：
2022-09-22
