Structure of MBP-Mcl-1 in complex with ABBV-467

Structure of MBP-Mcl-1 in complex with ABBV-467 Descriptor: (7R,16R)-19,23-dichloro-10-{[2-(4-{[(2R)-1,4-dioxan-2-yl]methoxy}phenyl)pyrimidin-4-yl]methoxy}-1-(4-fluorophenyl)-20,22-dimethyl-16-[(4-methylpiperazin-1-yl)methyl]-7,8,15,16-tetrahydro-18,21-etheno-13,9-(metheno)-6,14,17-trioxa-2-thia-3,5-diazacyclononadeca[1,2,3-cd]indene-7-carboxylic acid, Maltose/maltodextrin-binding periplasmic protein,Induced myeloid leukemia cell differentiation protein Mcl-1, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose Authors: Judge, R.A, Judd, A.S, Souers, A.J. Deposit date: 2022-09-22 Release date: 2023-10-25 Last modified: 2026-03-04 Method: X-RAY DIFFRACTION (2.406 Å) Cite: Selective MCL-1 inhibitor ABBV-467 is efficacious in tumor models but is associated with cardiac troponin increases in patients. Commun Med (Lond), 3, 2023与ABBV-467形成复合物的MBP-Mcl-1的结构 描述符：(7R,16R)-19,23-二氯-10-{[2-(4-{[(2R)-1,4-二氧六环-2-基]甲氧基}苯基)嘧啶-4-基]甲氧基}-1-(4-氟苯基)-20,22-二甲基-16-[(4-甲基哌嗪-1-基)甲基]-7,8,15,16-四氢-18,21-亚乙烯基-13,9-(甲川基)-6,14,17-三氧杂-2-硫杂-3,5-二氮杂环十九烷并[1,2,3-cd]茚-7-羧酸、麦芽糖/麦芽糖糊精结合周质蛋白（Maltose/maltodextrin-binding periplasmic protein）、诱导髓系白血病细胞分化蛋白Mcl-1（Induced myeloid leukemia cell differentiation protein Mcl-1）以及α-D-吡喃葡萄糖-(1→4)-α-D-吡喃葡萄糖 作者：Judge, R.A.、Judd, A.S.、Souers, A.J. 存档日期：2022-09-22 发布日期：2023-10-25 最后修改日期：2026-03-04 实验方法：X射线衍射（X-RAY DIFFRACTION），分辨率2.406埃（Å） 引用文献：选择性MCL-1抑制剂ABBV-467在肿瘤模型中具有抗肿瘤活性，但可导致患者心肌肌钙蛋白水平升高。《Commun Med (Lond)》，2023年，第3卷