Precise Gene Editing Preserves Hematopoietic Stem Cell Function Following Transient p53-Mediate DNA Damage Response [scRNA-seq]
收藏干细胞与再生医学数据中心2022-02-20 更新2024-03-06 收录
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We performed single-cell (sc)RNA-Seq on male donors FACS-sorted âprimitiveâ (CD34+ CD133+ CD90+) and âprogenitorâ (CD34+ CD133+ CD90-) HSPC cells treated with IL2RG ZFN, High Specificity (HS), (Low Specificity (LS) or control RNP in a ratio 1 to 1. We also included HS RNP and the cognate repair template containing a GFP expression cassette delivered by AAV6 and sorted for targeted integration (HS/AAV6 GFP+ vs. HS/AAV6 GFP-)
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CNR-ITB
创建时间：
2022-02-20
