Mitogen-activated protein kinase kinase 1 (MEK1) in complex with CH4987655 and MgAMP-PNP

Mitogen-activated protein kinase kinase 1 (MEK1) in complex with CH4987655 and MgAMP-PNP Descriptor: 3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]-N-(2-hydroxyethoxy)-5-[(3-oxo-1,2-oxazinan-2-yl)methyl]benzamide, Dual specificity mitogen-activated protein kinase kinase 1, MAGNESIUM ION, ... Authors: Lukacs, C.M, Janson, C, Schuck, V, Belunis, C. Deposit date: 2010-09-07 Release date: 2011-03-02 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Design and synthesis of novel allosteric MEK inhibitor CH4987655 as an orally available anticancer agent. Bioorg.Med.Chem.Lett., 21, 2011

与CH4987655及MgAMP-PNP结合的丝裂原活化蛋白激酶激酶1（Mitogen-activated protein kinase kinase 1, MEK1）。数据集描述：3,4-二氟-2-[(2-氟-4-碘苯基)氨基]-N-(2-羟基乙氧基)-5-[(3-氧代-1,2-恶嗪烷-2-基)甲基]苯甲酰胺、双特异性丝裂原活化蛋白激酶激酶1、镁离子……作者：Lukacs, C.M、Janson, C、Schuck, V、Belunis, C。存档日期：2010年9月7日；发布日期：2011年3月2日；最后修改日期：2024年2月21日。实验方法：X射线衍射（X-RAY DIFFRACTION，分辨率2.8 Å）。引用文献：《新型变构MEK抑制剂CH4987655的设计与合成：一种可口服抗癌剂》，《Bioorg.Med.Chem.Lett.》，2011年，第21卷。