Effects of dizocilpine, midazolam and their co-application on the trimethyltin (TMT)-induced rat model of neurodegeneration

The aim of this study was to explore the effect of NMDA receptor antagonist dizocilpine (MK-801) and GABAA receptor potentiator midazolam on the cognitive deficit and hippocampal cell loss induced by TMT and to investigate whether their co-application is associated with enhanced neuroprotective effects. Co-application of MK-801 and midazolam provided mild neuroprotective effect with respect to the histological parameters, while the compounds alone were largely ineffective. All three neuroprotective treatments induced similar degree of therapeutic effect in Morris water maze.本研究旨在探讨NMDA受体（N-methyl-D-aspartate receptor）拮抗剂地佐环平（dizocilpine，MK-801）与GABAA受体（γ-aminobutyric acid type A receptor）增强剂咪达唑仑对TMT诱导的认知缺陷及海马神经元丢失的影响，并探究二者联合应用能否增强神经保护效应。 联合应用MK-801与咪达唑仑可在组织学参数层面呈现轻度神经保护效果，而单独使用这两种化合物时基本无显著作用。三种神经保护干预方案在莫里斯水迷宫（Morris water maze）中均产生了程度相近的治疗效应。