T pallidum engineered to remove TprK donor cassettes

NIAID Data Ecosystem2026-03-14 收录

梅毒螺旋体基因编辑

抗原变异机制

数据链接：

https://www.ncbi.nlm.nih.gov/bioproject/PRJNA909291 数据链接链接失效反馈

官方服务：

资源简介：

Genomic sites that provide the donor cassettes for non-reciprocal gene conversion into the tprK expression site were knocked out

创建时间：

2022-12-06

DataSheet_3_Repeat-Driven Generation of Antigenic Diversity in a Major Human Pathogen, Trypanosoma cruzi.pdf

病原体基因组学

抗原变异机制

Trypanosoma cruzi, a zoonotic kinetoplastid protozoan parasite, is the causative agent of American trypanosomiasis (Chagas disease). Having a very plastic, repetitive and complex genome, the parasite

NIAID Data Ecosystem80

Trypanosoma brucei ribonuclease H2A is an essential enzyme that resolves R-loops associated with transcription initiation and antigenic variation

锥虫RNaseH2A功能

抗原变异机制

In every cell ribonucleotides inserted into DNA genomes represent a threat to the stability and transmission of the genetic material. Two types of Ribonuclease H (RNase H) enzyme are found in most org

NIAID Data Ecosystem60

Spatial integration of transcription and splicing in a dedicated compartment sustains monogenic antigen expression in African trypanosomes

抗原变异机制

基因表达调控

This repository contains the data for the manuscript https://doi.org/10.1038/s41564-020-00833-4. The HiC analysis pipeline can be found at https://github.com/bgbrink/PRJEB35632. Abstract Highly

NIAID Data Ecosystem30

Expression data of gene knockout Plasmodium falciparum clones

疟原虫表观遗传学

抗原变异机制

The variant antigen, Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1), expressed on the surface of P. falciparum infected Red Blood Cells (iRBCs) is a critical virulence factor for malari

NIAID Data Ecosystem60

Effect of a DSB at the active expression site

抗原变异机制

昆虫分子生物学

This study describes, for the first time, that a DSB embedded within the large block of 70 bp repeats in the active BES are not productive for VSG switching and that the position of a DSB in the activ

NIAID Data Ecosystem50

T pallidum engineered to remove TprK donor cassettes

资源简介：

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