Oxygen Controls Metabolic Flux and Influences Global Acetylation and Methylation in Human Pluripotent Stem Cells. Oxygen Controls Metabolic Flux and Influences Global Acetylation and Methylation in Human Pluripotent Stem Cells

Purpose: The goals of this study are to compare the effects of 5% and 20% oxygen culture on human embryonic stem cells, inlcuding the impact on their transcriptomes. Overall design: mRNA profiles of two human embryonic stem cell lines (MEL1 and MEL2) cultured long term at 5% and 20% oxygen.