Agent-based models predict emergent behavior of heterogeneous cell populations in dynamic microenvironments: POPULATION HETEROGENEITY (3/5)
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Data and results for `POPULATION HETEROGENEITY` simulations. Simulations of all possible combinations of four populations (X, A, B, C) under colony and tissue context with different levels of parameter heterogeneity (0, 0.1, 0.2, 0.3, 0.4, and 0.5). For tissue context, the healthy cell populations also varies parameter heterogeneity independent of the cancerous cell populations. Each condition is run for 15 days (21600 ticks) with 20 replicates (random seeds 0 - 19). Cells are introduced to the center of the constant source environment after a 1 day delay. Snapshots are taken every 0.5 days (720 ticks). The data folder contains .tar.xz compressed replicate sets. The data.param folder contains .tar.xz compressed replicate sets for .PARAM output. The results folder contains .pkl files of data parsed into arrays. Simulations are labeled as: [context]_[populations]_[population heterogeneity]_[background heterogeneity] - [context] - C = colony context, cancerous cell populations only - CH = tissue context, cancerous cell populations and healthy cells - [populations] - X = cancerous cell population with basal parameters - A = cancerous cell population with max_height x 1.5 - B = cancerous cell population with meta_pref x 1.5 - C = cancerous cell population with migra_threshold x 0.5 - [population heterogeneity] - ## = heterogeneity value for cancerous cell populations (##/10) - [background heterogeneity] - ## = heterogeneity value for healthy cell population (##/10) Additional data and results for this simulation set available at: - doi: 10.17632/bk9s769t3t - doi: 10.17632/mjpcm5my8z - doi: 10.17632/ynzsfdswjz - doi: 10.17632/p46dwfyvzg
种群异质性（POPULATION HETEROGENEITY）模拟相关数据与结果 本数据集包含四类种群（X、A、B、C）在菌落环境与组织环境下的全组合模拟实验，所有实验均设置了0、0.1、0.2、0.3、0.4、0.5共6个不同水平的参数异质性。 在组织环境场景中，健康细胞种群的参数异质性设置与癌细胞种群相互独立，可单独调整。 每个实验条件均运行15天（对应21600个时间步长），并开展20次重复实验（随机种子取值范围为0至19）。细胞将在1天的延迟后被接种至恒定源环境的中心区域。每0.5天（对应720个时间步长）采集一次系统快照。 `data`文件夹内存储了经`.tar.xz`压缩的重复实验数据集；`data.param`文件夹内存储了经`.tar.xz`压缩的`.PARAM`格式输出的重复实验数据集；`results`文件夹内存储了解析为数组格式的`.pkl`格式结果文件。 模拟实验的命名格式为：`[环境场景（context）]_[种群类型（populations）]_[癌细胞种群异质性（population heterogeneity）]_[健康细胞背景异质性（background heterogeneity）]` ## 命名字段详细说明 1. **环境场景（context）** - C：仅包含癌细胞种群的菌落环境 - CH：同时包含癌细胞与健康细胞的组织环境 2. **种群类型（populations）** - X：采用基础参数设置的癌细胞种群 - A：最大增殖高度（max_height）为基础值1.5倍的癌细胞种群 - B：迁移偏好（meta_pref）为基础值1.5倍的癌细胞种群 - C：迁移阈值（migra_threshold）为基础值0.5倍的癌细胞种群 3. **癌细胞种群异质性（population heterogeneity）** - ##：癌细胞种群的异质性水平，实际取值为##/10 4. **健康细胞背景异质性（background heterogeneity）** - ##：健康细胞种群的异质性水平，实际取值为##/10 本模拟集的额外数据与结果可通过以下DOI获取： - doi: 10.17632/bk9s769t3t - doi: 10.17632/mjpcm5my8z - doi: 10.17632/ynzsfdswjz - doi: 10.17632/p46dwfyvzg
