Nanomedicines in oral cancer: inspiration comes from extracellular vesicles and biomimetic nanoparticles - Supplementary dataset

Oral cancer is a common life-threatening malignancy having high mortality and morbidity rates. During
the treatment process, individuals unavoidably experience severe side effects. It is essential to develop
safer and more effective strategies. Currently, extracellular vesicles (EVs) and biomimetic nanoparticles are
nanomedicines with long-term blood circulation and lower off-target toxicity that orchestrate immune
responses and accumulate specifically in tumor sites. EVs create a synergetic effect by encapsulating
drugs and collaborating with naturally loaded elements in the EVs. Biomimetic nanoparticles retain the
characteristic features of the synthetic nanocarriers and inherit the intrinsic cellmembrane functionalities.
This review outlines the properties, applications, challenges, pros and cons of EVs and biomimetic
nanoparticles, providing novel perspectives on oral cancer.