Redirection coefficient values and effects.

Values of flat and power series redirection coefficients for selected target enzymes found in the optimization for myristoyl-CoA, neighborhood size 6 at iteration 15. Total flux change represents the summation of all flux changes to the reactions that the enzyme controls for the flat redirection coefficients. Flux change count gives an overview of how the fluxes, associated with each enzyme, change as a result of this design. Flux change is calculated by comparing the value of the flux at current optimal system objective to those found during optimal growth. We indicate the number of reactions with flux levels that decrease (−), stay the same (no change), or increase (+).