Eda

Predicted to enable cytokine activity; death receptor agonist activity; and death receptor binding activity. Acts upstream of or within several processes, including hair follicle placode formation; positive regulation of signal transduction; and trachea gland development. Located in apical part of cell; endoplasmic reticulum membrane; and plasma membrane. Is expressed in several structures, including embryo ectoderm; exocrine system; facial prominence; nasal gland epithelium; and oral region epithelium. Used to study hypohidrotic ectodermal dysplasia. Human ortholog(s) of this gene implicated in ectodermal dysplasia 1 and tooth agenesis. Orthologous to human EDA (ectodysplasin A). [provided by Alliance of Genome Resources, Nov 2024]

此基因预测具有调控细胞因子活性、死亡受体激动剂活性和死亡受体结合活性的功能；其在多个生命过程上游或其中发挥作用，包括毛囊原基形成、信号转导的正向调控以及气管腺的发育。该基因定位于细胞顶端部分、内质网膜和质膜。在多个结构中表达，包括胚胎外胚层、外分泌系统、面部突出部分、鼻腺上皮以及口腔区域上皮。用于研究少汗性外胚层发育不良。此基因的人类同源基因与外胚层发育不良1和牙齿发育不全有关，与人类Ectodysplasin A (EDA) 基因同源。[由基因组资源联盟提供，2024年11月]