Dot1 and Histone H3K79 Methylation in Natural Heterochromatic and HML/HMR Silencing

Dot1 is a methyl transferase that has been shown through a reporter gene to be involved in position effect variegation of gene expression in heterochrmatic regions such as telomeres and the mating type loci in yeastDot1是一种甲基转移酶，经报告基因（reporter gene）实验验证，其参与酵母端粒（telomeres）、交配型位点（mating type loci）等异染色质区域内基因表达的位置效应斑驳（position effect variegation）过程。