Carrier frequency and absolute risk for HLA allele groups associated to NAb development and biologically relevant titersa.

aAll HLA allele groups can be found in Table S5.bTreatment only is the frequency of NAb development and biologically relevant titers for each treatment regardless of genotype.cThe absolute risk for each HLA allele group is calculated with Bayes' theorem and assessed based on frequency and impact on NAb development.dNominal P-values from Fishers exact test.eBonferroni corrected P-values (allele groups tested: 12 tests for i.m. IFNβ-1a, 19 tests for IFNβ-1b, 38 for s.c. IFNβ-1a).Abbreviations: AR = absolute risk, C.I. = confidence interval, OR = odds ratio, IFNβ = interferon beta, n/a = not applicable, NAb = neutralizing antibodies.