Generation of Memory T cells In Young Healthy and Immunocompromised Populations

To expand our study of T cell memory repertoires to include healthy children who should still be in the process of generating memory repertoires. These studies will provide data about the age dynamics of memory repertoires. In addition to children, we will examine flu-specific memory repertoires in children with autoimmune diseases who are undergoing mild immunosuppression. This should describe the effects of immunosuppressive therapy on memory formation and function.