Methylation of cytosine at C5 in a CpG sequence context causes a conformational switch of a benzo[a]pyrene diol epoxide-N2-guanine adduct in DNA from a minor groove alignment to intercalation with base displacement

Methylation of cytosine at C5 in a CpG sequence context causes a conformational switch of a benzo[a]pyrene diol epoxide-N2-guanine adduct in DNA from a minor groove alignment to intercalation with base displacement Descriptor: 1,2,3-TRIHYDROXY-1,2,3,4-TETRAHYDROBENZO[A]PYRENE, 5'-D(*CP*CP*AP*TP*(5CM)P*(BPG)P*CP*TP*AP*CP*C)-3', 5'-D(*GP*GP*TP*AP*GP*CP*GP*AP*TP*GP*G)-3' Authors: Zhang, N, Lin, C, Huang, X, Kolbanovskiy, A, Hingerty, B.E, Amin, S, Broyde, S, Geacintov, N.E, Patel, D.J. Deposit date: 2004-12-15 Release date: 2005-03-22 Last modified: 2024-04-24 Method: SOLUTION NMR Cite: Methylation of cytosine at C5 in a CpG sequence context causes a conformational switch of a benzo[a]pyrene diol epoxide-N2-guanine adduct in DNA from a minor groove alignment to intercalation with base displacement. J.Mol.Biol., 346, 2005

CpG序列背景下胞嘧啶C5位的甲基化可使DNA中苯并[a]芘二醇环氧化物-N2-鸟嘌呤加合物的构象发生切换，从小沟取向转变为碱基置换型插入构象。描述项：1,2,3-三羟基-1,2,3,4-四氢苯并[a]芘（1,2,3-TRIHYDROXY-1,2,3,4-TETRAHYDROBENZO[A]PYRENE）、5'-D(*CP*CP*AP*TP*(5CM)P*(BPG)P*CP*TP*AP*CP*C)-3'、5'-D(*GP*GP*TP*AP*GP*CP*GP*AP*TP*GP*G)-3'。作者：Zhang, N、Lin, C、Huang, X、Kolbanovskiy, A、Hingerty, B.E、Amin, S、Broyde, S、Geacintov, N.E、Patel, D.J.。存档日期：2004-12-15；发布日期：2005-03-22；最后修改日期：2024-04-24。实验方法：溶液核磁共振（SOLUTION NMR）。引用文献：CpG序列背景下胞嘧啶C5位的甲基化可引发DNA中苯并[a]芘二醇环氧化物-N2-鸟嘌呤加合物的构象转换，从小沟排列变为碱基置换型插入构象。J.Mol.Biol., 346, 2005