ActivinA effect on mouse articular chondrocytes. ActivinA effect on mouse articular chondrocytes

Gene expression profiling of mouse articular chondrocytes infected with Ad-C or Ad-Activin A In this study, we have attempted to explore the effects of Activin A and have identified numerous genes which are involved in osteoarthritis pathogenesis. Overall design: mouse articular chondrocytes were isolated from mouse femoral condyles and tibial plateaus cartilage tissue and infected with Ad-C(control) or Ad-ActivinA for 36 hours. Total RNA was extracted from primary mouse articular chondrocytes cultured with Ad-C (2 biological replicates) or Ad-activinA for 36 hours (2 biological replicates) and subjected to microarray analysis.