NINDS-Genome-Wide Genotyping in Parkinson's Disease: First Stage Analysis and Public Release of Data. NINDS-Genome-Wide Genotyping in Parkinson's Disease: First Stage Analysis and Public Release of Data

Epidemiological studies have estimated a cumulative prevalence of PD of greater than 1 per thousand. When prevalence is limited to senior populations, this proportion increases nearly 10-fold. The estimated genetic risk ratio for PD is approximately 1.7 (70% increased risk for PD if a sibling has PD) for all ages, and increases over 7-fold for those under age 66 years. The role for genes contributing to the risk of PD is therefore significant. This study utilized the well characterized http://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?id=phs000003, and http://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?id=phs000004 from the sample population which are banked in the National Institute of Neurological Disorders and Stroke (NINDS Repository) collection for a first stage whole genome analysis. Genome-wide, single nucleotide polymorphism (SNP) genotyping of these publicly available samples was originally done in 267 Parkinson's disease patients... (for more see dbGaP study page.)