Higher levels of cardiovascular biomarkers following hypertensive compared to normotensive pregnancy

Hypertensive disorder of pregnancy (HDP) is associated with an increased risk for later-life cardiovascular disease (CVD). Whether the HDP pregnancy itself confers risk toward CVD later in life is suggested in several epidemiologic studies. Given this connection and that the HDP exposure itself may play a role, understanding whether markers associated with cardiovascular risk vary based on HDP history in the years following pregnancy may assist with risk stratification and development of targeted interventions. We measured 77 proteins (CVD-associated and inflammatory markers) in n = 22 individuals with a history of HDP and n = 42 matched controls with no HDP history at a median of 4 years after pregnancy. Several CVD-associated proteins (fibrinogen, fetuin-A, L-selectin, and alpha-1-acid glycoprotein) were significantly elevated, by orders of magnitude, in individuals with a history of HDP compared to normotensive pregnancies (all p < 0.0001). In multivariable linear regression model..., Clinical metadata was abstracted from electronic health records by trained obstetric providers. 
, , # Higher levels of cardiovascular biomarkers following hypertensive compared to normotensive pregnancy

[https://doi.org/10.5061/dryad.rn8pk0pmc](https://doi.org/10.5061/dryad.rn8pk0pmc)

Results are from a case-control study of participants several years after a pregnancy complicated by a hypertensive disorder of pregnancy (HDP) or prior normotensive pregnancies. The post-HDP cohort includes n=22 participants, while the post-Normal cohort includes n=42 participants. 

## Description of the data and file structure

1. *deidentified_metadata.xls*: Excel file containing de-identified clinical metadata for all participants. 
2. *deidentified_metadata_codebook.xls*: Codebook for variables in \"deidentified_metadata.xls\". Note that cells with \".\" indicate missing data. 
3. *protein_concentration_legend.xlsx*: Excel file containing legend for raw protein concentration values. 
4. *cvd_proteins_1_plasma.xlsx*: Excel file containing raw concentration values of 6 cardiovascular disease (CVD)-asso..., We received informed consent from participants to publish the de-identified data in the public domain. All data is de-identified. Each participants is noted with an anonymized studyID and no direct identifiers are included.